Our goal is to reveal novel macromolecular interactions, up to the level of whole cells, by means of cryo-electron tomography and advanced pattern recognition algorithms. Cryo-electron tomography is the only technique that can obtain molecular resolution images of intact cells in a quasi-native state.
In addition, we are using classical biological room temperature electron micoscopy. Ultrastructural preservation is assured in these preparations by prior high pressure freezing. We use this method to image larger volumina, as e.g. tissues and whole model organisms (currently C. elegans and Drosophila embryos) by focussed ion beam scanning electron microscopy and (after ultramicrotomy) by room temperature tomography.
We offer special lectures and courses in Electron Microscopy and Image Processing for physic, biophysic, biochemistry, chemistry and biology students. Our aim is to teach you the main principles of both methods and give you an understanding for their impact in modern Life Sciences.
iMOL is committed to training PhD students in the theory and practice of advanced microscopy methods and cutting-edge image analysis. Microscopy is instrumental to our understanding of the basic principles of life at multiple spatio-temporal scales and resolutions. Central to iMOL are hypothesis-driven life science applications that challenge textbook knowledge at the molecular scale. For this novel research program that interfaces image analysis with molecular life science we are seeking PhD students with degrees in neuroscience, biochemistry, physics, biology or computer science to work synergistically.